Mending the heart and mind during times of loss: a review of interventions to improve emotional well-being during spousal bereavement
Keywords:
bereavement, spousal, interventions, emotion, griefAbstract
AbstractSpousal loss is one of life’s greatest stressors. Bereaved spouses are at risk for aberrant cognitive and affective processing. Recent work in psychoneuroimmunology and cognitive neuroscience reveals physiological biomarkers and neural mechanisms underlying acute distress and grief during bereavement that may represent targets for future interventions. We review evidence from existing pharmacological and psychotherapeutic treatment approaches for normal bereavement, complicated grief, and bereavement-related depression. We propose promising future directions, namely the development and empirical validation of novel, personalised cognitive and neurostimulatory interventions to promote adaptive emotion regulation and reduce depressive symptoms following spousal loss. Future work may substantiate which interventions to improve emotional and physical health will be best matched to the needs of a particular surviving spouse.
References
Abbasi, S.H., Hosseini, F., Modabbernia, A., Ashrafi, M., & Akhondzadeh, S. (2012). Effect of celecoxib add-on treatment on symptoms and serum IL-6 concentrations in patients with major depressive disorder: randomized double-blind placebo-controlled study. Journal of Affective Disorders, 141(2–3), 308–314. https://doi.org/10.1016/j.jad.2012.03.033
Akhtar, H., Bukhari, F., Nazir, M., Anwar, M. N., & Shahzad, A. (2016). Therapeutic efficacy of neurostimulation for depression: techniques, current modalities, and future challenges. Neuroscience Bulletin, 32(1), 115–126. https://doi.org/10.1007/s12264-015-0009-2
Aldao, A., Nolen-Hoeksema, S., & Schweizer, S. (2010). Emotion-regulation strategies across psychopathology: a meta-analytic review. Clinical Psychology Review, 30(2), 217–237. https://doi.org/10.1016/j.cpr.2009.11.004
Allan, C., Kalu, U.-G., Sexton, C. E., & Ebmeier, K. P. (2012). Transcranial stimulation in depression. The British Journal of Psychiatry: The Journal of Mental Science, 200(1), 10–11. https://doi.org/10.1192/bjp.bp.111.101188
American Psychiatric Association. (2013). Diagnostic and Statistical Manual of mental Disorders (5th ed.). Arlington, VA: American Psychiatric Association.
American Association of Retired Persons. (2001). Bereaved spouses report. Washington, D.C.: AARP.
Aneshensel, C. S., Botticello, A. L., & Yamamoto-Mitani, N. (2004). When caregiving ends: the course of depressive symptoms after bereavement. Journal of Health and Social Behavior, 45(4), 422–440. https://doi.org/10.1177/002214650404500405.
Beauregard, M., Lévesque, J., & Bourgouin, P. (2001). Neural correlates of conscious self-regulation of emotion. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 21(18), RC165.
Bergman, E. J., & Haley, W. E. (2009). Depressive symptoms, social network, and bereavement service utilization and preferences among spouses of former hospice patients. Journal of Palliative Medicine, 12(2), 170–176. https://doi.org/10.1089/jpm.2008.0237.
Berking, M., Wupperman, P., Reichardt, A., Pejic, T., Dippel, A., & Znoj, H. (2008). Emotion-regulation skills as a treatment target in psychotherapy. Behaviour Research and Therapy, 46(11), 1230–1237. https://doi.org/10.1016/j.brat.2008.08.005.
Bonanno, G. A. (2004). Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? The American Psychologist, 59(1), 20–28. https://doi.org/10.1037/0003-066X.59.1.20
Bonanno, G. A. (2005). Resilience in the face of potential trauma. Current Directions in Psychological Science, 14(3), 135–138. https://doi.org/10.1111/j.0963-7214.2005.00347.x
Buckley, T., Sunari, D., Marshall, A., Bartrop, R., McKinley, S., & Tofler, G. (2012). Physiological correlates of bereavement and the impact of bereavement interventions. Dialogues in Clinical Neuroscience, 14(2), 129–139.
Burklund, L. J., Creswell, J. D., Irwin, M. R., & Lieberman, M. D. (2014). The common and distinct neural bases of affect labeling and reappraisal in healthy adults. Frontiers in Psychology, 5. https://doi.org/10.3389/fpsyg.2014.00221.
Bush, G., Vogt, B. A., Holmes, J., Dale, A. M., Greve, D., Jenike, M. A., & Rosen, B. R. (2002). Dorsal anterior cingulate cortex: a role in reward-based decision making. Proceedings of the National Academy of Sciences of the United States of America, 99(1), 523–528. https://doi.org/10.1073/pnas.012470999
Cacciatore, J., Thieleman, K., Osborn, J., & Orlowski, K. (2014). Of the soul and suffering: mindfulness-based interventions and bereavement. Clinical Social Work Journal, 42(3), 269–281. https://doi.org/10.1007/s10615-013-0465-y
Carlsson, M. E., & Nilsson, I. M. (2007). Bereaved spouses’ adjustment after the patients’ death in palliative care. Palliative & Supportive Care, 5(4), 397–404.
Carr, D. & Jeffreys, J. (2011). Spousal bereavement in later life. In R.Neimeyer, D.Harris, H.Winokuer, & G.Thornton (Eds.), Grief and bereavement in contemporary society: bridging research and practice (pp. 81-92). New York: Routledge.
Clayton, P., Desmarais, L., & Winokur, G. (1968). A study of normal bereavement. American Journal of Psychiatry, 125(2), 168–178. https://doi.org/10.1176/ajp.125.2.168
Cohen, M., Granger, S., & Fuller-Thomson, E. (2015). The association between bereavement and biomarkers of inflammation. Behavioral Medicine, 41(2), 49–59. https://doi.org/10.1080/08964289.2013.866539
Critchley, H. D., Mathias, C. J., Josephs, O., O’Doherty, J., Zanini, S., Dewar, B.-K., … Dolan, R. J. (2003). Human cingulate cortex and autonomic control: converging neuroimaging and clinical evidence. Brain: A Journal of Neurology, 126(Pt 10), 2139–2152. https://doi.org/10.1093/brain/awg216
Currier, J. M., Holland, J. M., & Neimeyer, R. A. (2010). Do CBT-based interventions alleviate distress following bereavement? A review of the current evidence. PubMed Health. Retrieved from https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0031114/
Currier, J. M., Neimeyer, R. A., & Berman, J. S. (2008). The effectiveness of psychotherapeutic interventions for bereaved persons: a comprehensive quantitative review. Psychological Bulletin, 134(5), 648–661. https://doi.org/10.1037/0033-2909.134.5.648
Denny, B. T., Inhoff, M. C., Zerubavel, N., Davachi, L., & Ochsner, K. N. (2015). Getting Over It: long-lasting effects of emotion regulation on amygdala response. Psychological Science, 26(9), 1377–1388. https://doi.org/10.1177/0956797615578863
Denny, B. T., & Ochsner, K. N. (2014). Behavioral effects of longitudinal training in cognitive reappraisal. Emotion (Washington, D.C.), 14(2), 425–433. https://doi.org/10.1037/a0035276
Diamond, L. M., Fagundes, C. P., & Cribbet, M. R. (2012). Individual differences in adolescents’ sympathetic and parasympathetic functioning moderate associations between family environment and psychosocial adjustment. Developmental Psychology, 48(4), 918–931. https://doi.org/10.1037/a0026901
Doré, B. P., Silvers, J. A., & Ochsner, K. N. (2016). Toward a personalized science of emotion regulation. Social and Personality Psychology Compass, 10(4), 171–187. https://doi.org/10.1111/spc3.12240
Fagundes, C. P., Glaser, R., Hwang, B. S., Malarkey, W. B., & Kiecolt-Glaser, J. K. (2013). Depressive symptoms enhance stress-induced inflammatory responses. Brain, Behavior, and Immunity, 31, 172–176. https://doi.org/10.1016/j.bbi.2012.05.006
Fagundes, C. P., & Schindler, I. (2012). Making of romantic attachment bonds: longitudinal trajectories and implications for relationship stability. Personal Relationships, 19(4), 723–742. https://doi.org/10.1111/j.1475-6811.2011.01389.x
Field, N. P., Gao, B., & Paderna, L. (2005). Continuing bonds in bereavement: an attachment theory based perspective. Death Studies, 29(4), 277–299. https://doi.org/10.1080/07481180590923689
Gauthier, L. R., & Gagliese, L. (2012). Bereavement interventions, end-of-life cancer care, and spousal well-being: a systematic review. Clinical Psychology: Science and Practice, 19(1), 72–92. https://doi.org/10.1111/j.1468-2850.2012.01275.x
George, M. S., Nahas, Z., Molloy, M., Speer, A. M., Oliver, N. C., Li, X. B., … Ballenger, J. C. (2000). A controlled trial of daily left prefrontal cortex TMS for treating depression. Biological Psychiatry, 48(10), 962–970.
Glaser, R., Robles, T. F., Sheridan, J., Malarkey, W. B., & Kiecolt-Glaser, J. K. (2003). Mild depressive symptoms are associated with amplified and prolonged inflammatory responses after influenza virus vaccination in older adults. Archives of General Psychiatry, 60(10), 1009–1014. https://doi.org/10.1001/archpsyc.60.10.1009
Gross, J. (1998). The emerging field of emotion regulation: an integrative review. Review of General Psychology, 2(3), 271–299. https://doi.org/10.1037/1089-2680.2.3.271
Gross, J. (2015). Emotion regulation: current status and future prospects, Psychological Inquiry, 26(1), 1-26. https://doi.org/10.1080/1047840X.2014.940781
Gross, J. J., & Thompson, R. A. (2007). Emotion regulation: conceptual foundations. In J. J.Gross (Ed.), Handbook of emotion regulation (pp. 3-24). New York: Guilford Press.
Hofmann, S. G., Asnaani, A., Vonk, I. J. J., Sawyer, A. T., & Fang, A. (2012). The efficacy of Cognitive Behavioral Therapy: a review of meta-analyses. Cognitive Therapy and Research, 36(5), 427–440. https://doi.org/10.1007/s10608-012-9476-1
Houldin, A. D., McCorkle, R., & Lowery, B. J. (1993). Relaxation training and psychoimmunological status of bereaved spouses. A pilot study. Cancer Nursing, 16(1), 47–52.
Irwin, M. (2002). Psychoneuroimmunology of depression: clinical implications. Brain, Behavior, and Immunity, 16(1), 1–16. https://doi.org/10.1006/brbi.2001.0654
Jacobs, S. C., Nelson, J. C., & Zisook, S. (1987). Treating depressions of bereavement with antidepressants. A pilot study. The Psychiatric Clinics of North America, 10(3), 501–510.
Jaremka, L. M., Andridge, R. R., Fagundes, C. P., Alfano, C. M., Povoski, S. P., Lipari, A. M., … Kiecolt-Glaser, J. K. (2014). Pain, depression, and fatigue: loneliness as a longitudinal risk factor. Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association, 33(9), 948–957. https://doi.org/10.1037/a0034012
Johnson, J. D., O’Connor, K. A., Deak, T., Spencer, R. L., Watkins, L. R., & Maier, S. F. (2002a). Prior stressor exposure primes the HPA axis. Psychoneuroendocrinology, 27(3), 353–365.
Johnson, J. D., O’Connor, K. A., Deak, T., Stark, M., Watkins, L. R., & Maier, S. F. (2002b). Prior stressor exposure sensitizes LPS-induced cytokine production. Brain, Behavior, and Immunity, 16(4), 461–476.
Kalisch, R., Wiech, K., Critchley, H. D., Seymour, B., O’Doherty, J. P., Oakley, D. A., … Dolan, R. J. (2005). Anxiety reduction through detachment: subjective, physiological, and neural effects. Journal of Cognitive Neuroscience, 17(6), 874–883. https://doi.org/10.1162/0898929054021184
Kiecolt-Glaser, J. K., Derry, H. M., & Fagundes, C. P. (2015). Inflammation: depression fans the flames and feasts on the heat. The American Journal of Psychiatry, 172(11), 1075–1091. https://doi.org/10.1176/appi.ajp.2015.15020152
Kross, E., & Ayduk, O. (2017). Chapter Two - Self-distancing: theory, research, and current directions. In J. M.Olson (Ed.), Advances in Experimental Social Psychology (Vol. 55, pp. 81–136). Academic Press. https://doi.org/10.1016/bs.aesp.2016.10.002
Lieberman, M. A., & Yalom, I. (1992). Brief group psychotherapy for the spousally bereaved: a controlled study. International Journal of Group Psychotherapy, 42(1), 117–132.
Lieberman, M. D., Eisenberger, N. I., Crockett, M. J., Tom, S. M., Pfeifer, J. H., & Way, B. M. (2007). Putting feelings into words: affect labeling disrupts amygdala activity in response to affective stimuli. Psychological Science, 18(5), 421–428. https://doi.org/10.1111/j.1467-9280.2007.01916.x
Lipsman, N., Sankar, T., Downar, J., Kennedy, S. H., Lozano, A. M., & Giacobbe, P. (2014). Neuromodulation for treatment-refractory major depressive disorder. CMAJ : Canadian Medical Association Journal, 186(1), 33–39. https://doi.org/10.1503/cmaj.121317
Luc, G., Bard, J.-M., Juhan-Vague, I., Ferrieres, J., Evans, A., Amouyel, P., … PRIME Study Group. (2003). C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease: the PRIME Study. Arteriosclerosis, Thrombosis, and Vascular Biology, 23(7), 1255–1261. https://doi.org/10.1161/01.ATV.0000079512.66448.1D
Lund, D. A., & Caserta, M. S. (1992). Older bereaved spouses’ participation in self-help groups. OMEGA - Journal of Death and Dying, 25(1), 47–61. https://doi.org/10.2190/0F2E-96VY-419K-KXAA
Lund, D., Caserta, M., Utz, R., & de Vries, B. (2010). Experiences and early coping of bereaved spouses/partners in an intervention based on the Dual Process Model (DPM). Omega, 61(4), 291–313.
Lyubomirsky, S., Sousa, L., & Dickerhoof, R. (2006). The costs and benefits of writing, talking, and thinking about life’s triumphs and defeats. Journal of Personality and Social Psychology, 90(4), 692–708. https://doi.org/10.1037/0022-3514.90.4.692
Maciejewski, P. K., Zhang, B., Block, S. D., & Prigerson, H. G. (2007). An empirical examination of the Stage Theory of Grief. JAMA, 297(7), 716–723. https://doi.org/10.1001/jama.297.7.716
Maddock, R. J., Garrett, A. S., & Buonocore, M. H. (2001). Remembering familiar people: the posterior cingulate cortex and autobiographical memory retrieval. Neuroscience, 104(3), 667–676.
Maddock, R. J., Garrett, A. S., & Buonocore, M. H. (2003). Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task. Human Brain Mapping, 18(1), 30–41. https://doi.org/10.1002/hbm.10075
Maes, M., Song, C., Lin, A., De Jongh, R., Van Gastel, A., Kenis, G., … Smith, R. S. (1998). The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine, 10(4), 313–318.
Malkinson, R. (1996). Cognitive behavioral grief therapy. Journal of Rational-Emotive and Cognitive-Behavior Therapy, 14(3), 155–171. https://doi.org/10.1007/BF02238267
Martikainen, P., & Valkonen, T. (1996). Mortality after the death of a spouse: rates and causes of death in a large Finnish cohort. American Journal of Public Health, 86(8_Pt_1), 1087–1093. https://doi.org/10.2105/AJPH.86.8_Pt_1.1087
McRae, K., Ciesielski, B., & Gross, J. J. (2012). Unpacking cognitive reappraisal: goals, tactics, and outcomes. Emotion (Washington, D.C.), 12(2), 250–255. https://doi.org/10.1037/a0026351
McRae, K., & Mauss, I. B. (2016). Increasing positive emotion in negative contexts: Emotional consequences, neural correlates, and implications for resilience. In J. D.Greene, I.Morrison, & M. E. P.Seligman (Eds.), Positive neuroscience (pp. 159–174). New York: Oxford University Press
Mendall, M. A., Patel, P., Asante, M., Ballam, L., Morris, J., Strachan, D. P., … Northfield, T. C. (1997). Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease. Heart (British Cardiac Society), 78(3), 273–277.
Milev, R. V., Giacobbe, P., Kennedy, S. H., Blumberger, D. M., Daskalakis, Z. J., Downar, J., … CANMAT Depression Work Group. (2016). Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical guidelines for the management of adults with major depressive disorder: Section 4. Neurostimulation treatments. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie, 61(9), 561–575. https://doi.org/10.1177/0706743716660033
Miller, E. K., & Cohen, J. D. (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24, 167–202. https://doi.org/10.1146/annurev.neuro.24.1.167
Monk, T. H., Germain, A., & Reynolds, C. F. (2008). Sleep disturbance in bereavement. Psychiatric Annals, 38(10), 671–675.
Mostofsky, E., Maclure, M., Sherwood, J. B., Tofler, G. H., Muller, J. E., & Mittleman, M. A. (2012). Risk of acute myocardial infarction after the death of a significant person in one’s life: the Determinants of Myocardial Infarction Onset Study. Circulation, 125(3), 491–496. https://doi.org/10.1161/CIRCULATIONAHA.111.061770
Murphy, F. C., Nimmo-Smith, I., & Lawrence, A. D. (2003). Functional neuroanatomy of emotions: a meta-analysis. Cognitive, Affective & Behavioral Neuroscience, 3(3), 207–233.
National Health Service, UK. (2017). Talk therapy. Retrieved from http://www.nhs.uk/Conditions/stress-anxiety-depression/Pages/types-of-therapy.aspx.
Neimeyer, R. A. (2000). Searching for the meaning of meaning: grief therapy and the process of reconstruction. Death Studies, 24(6), 541–558. https://doi.org/10.1080/07481180050121480
Nseir, S., & Larkey, L. K. (2013). Interventions for spousal bereavement in the older adult: an evidence review. Death Studies, 37(6), 495–512. https://doi.org/10.1080/07481187.2011.649941
Ochsner, K. N., Ray, R. D., Cooper, J. C., Robertson, E. R., Chopra, S., Gabrieli, J. D. E., & Gross, J. J. (2004). For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion. NeuroImage, 23(2), 483–499. https://doi.org/10.1016/j.neuroimage.2004.06.030
O’Connor, M., Piet, J., & Hougaard, E. (2014). The effects of mindfulness-cased cognitive therapy on depressive symptoms in elderly bereaved people with loss-related distress: a controlled pilot study. Mindfulness, 5(4), 400–409. https://doi.org/10.1007/s12671-013-0194-x
Ott, C. H., Lueger, R. J., Kelber, S. T., & Prigerson, H. G. (2007). Spousal bereavement in older adults: common, resilient, and chronic grief with defining characteristics. The Journal of Nervous and Mental Disease, 195(4), 332–341. https://doi.org/10.1097/01.nmd.0000243890.93992.1e
Pai, J. K., Pischon, T., Ma, J., Manson, J. E., Hankinson, S. E., Joshipura, K., … Rimm, E. B. (2004). Inflammatory markers and the risk of coronary heart disease in men and women. The New England Journal of Medicine, 351(25), 2599–2610. https://doi.org/10.1056/NEJMoa040967
Parkes, C. M., Benjamin, B., & Fitzgerald, R. G. (1969). Broken heart: a statistical study of increased mortality among widowers. British Medical Journal, 1(5646), 740–743.
Pasternak, R. E., Reynolds, C. F., Schlernitzauer, M., Hoch, C. C., Buysse, D. J., Houck, P. R., & Perel, J. M. (1991). Acute open-trial nortriptyline therapy of bereavement-related depression in late life. The Journal of Clinical Psychiatry, 52(7), 307–310.
Pfoff, M. K., Zarotney, J. R., & Monk, T. H. (2014). Can a function-based therapy for spousally bereaved seniors accrue benefits in both functional and emotional domains? Death Studies, 38(6–10), 381–386. https://doi.org/10.1080/07481187.2013.766658
Prigerson, H. G., Horowitz, M. J., Jacobs, S. C., Parkes, C. M., Aslan, M., Goodkin, K., … Maciejewski, P. K. (2009). Prolonged grief disorder: Psychometric validation of criteria proposed for DSM-V and ICD-11. PLoS Medicine, 6(8), e1000121. https://doi.org/10.1371/journal.pmed.1000121
Reynolds, C. F., Miller, M. D., Pasternak, R. E., Frank, E., Perel, J. M., Cornes, C., … Kupfer, D. J. (1999). Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapy. The American Journal of Psychiatry, 156(2), 202–208. https://doi.org/10.1176/ajp.156.2.202
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000). Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation, 101(15), 1767–1772.
Robinaugh, D. J., LeBlanc, N. J., Vuletich, H. A., & McNally, R. J. (2014). Network analysis of persistent complex bereavement disorder in conjugally bereaved adults. Journal of Abnormal Psychology, 123(3), 510–522. https://doi.org/10.1037/abn0000002
Segal, D. L., Bogaards, J. A., Becker, L. A., & Chatman, C. (1999). Effects of emotional expression on adjustment to spousal loss among older adults. Journal of Mental Health and Aging, 5(4), 297–310.
Shear, M. K., Ghesquiere, A., & Glickman, K. (2013). Bereavement and complicated grief. Current Psychiatry Reports, 15(11), 406. https://doi.org/10.1007/s11920-013-0406-z
Shear, M. K., & Mulhare, E. (2008). Complicated Grief. Psychiatric Annals, 38(10). https://doi.org/10.3928/00485713-20081001-10
Shenhav, A., Botvinick, M. M., & Cohen, J. D. (2013). The expected value of control: an integrative theory of anterior cingulate cortex function. Neuron, 79(2), 217–240. https://doi.org/10.1016/j.neuron.2013.07.007
Shenhav, A., Cohen, J. D., & Botvinick, M. M. (2016). Dorsal anterior cingulate cortex and the value of control. Nature Neuroscience, 19(10), 1286–1291. https://doi.org/10.1038/nn.4384
Siegle, G. J., Thompson, W. K., Collier, A., Berman, S. R., Feldmiller, J., Thase, M. E., & Friedman, E. S. (2012). Toward clinically useful neuroimaging in depression treatment: prognostic utility of subgenual cingulate activity for determining depression outcome in cognitive therapy across studies, scanners, and patient characteristics. Archives of General Psychiatry, 69(9), 913–924. https://doi.org/10.1001/archgenpsychiatry.2012.65
Silva, A. C., de Oliveira Ribeiro, N. P., de Mello Schier, A. R., Arias-Carrión, O., Paes, F., Nardi, A. E., … Pessoa, T. M. (2014). Neurological aspects of grief. CNS & Neurological Disorders Drug Targets, 13(6), 930–936.
Simon, N. M., Shear, K. M., Thompson, E. H., Zalta, A. K., Perlman, C., Reynolds, C. F., … Silowash, R. (2007). The prevalence and correlates of psychiatric comorbidity in individuals with complicated grief. Comprehensive Psychiatry, 48(5), 395–399. https://doi.org/10.1016/j.comppsych.2007.05.002
Stroebe, M., & Schut, H. (1999). The dual process model of coping with bereavement: rationale and description. Death Studies, 23(3), 197–224. https://doi.org/10.1080/074811899201046
Stroebe, M., Schut, H., & Stroebe, W. (2007). Health outcomes of bereavement. Lancet (London, England), 370(9603), 1960–1973. https://doi.org/10.1016/S0140-6736(07)61816-9
Troy, A. S., Wilhelm, F. H., Shallcross, A. J., & Mauss, I. B. (2010). Seeing the silver lining: cognitive reappraisal ability moderates the relationship between stress and depressive symptoms. Emotion (Washington, D.C.), 10(6), 783–795. https://doi.org/10.1037/a0020262
UK ECT Review Group. (2003). Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet (London, England), 361(9360), 799–808. https://doi.org/10.1016/S0140-6736(03)12705-5
Varbo, A., Benn, M., Tybjærg-Hansen, A., & Nordestgaard, B. G. (2013). Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation. Circulation, 128(12), 1298–1309. https://doi.org/10.1161/CIRCULATIONAHA.113.003008
Vassena, E., Holroyd, C. B., & Alexander, W. H. (2017). Computational models of anterior cingulate cortex: at the crossroads between prediction and effort. Frontiers in Neuroscience, 11, 316. https://doi.org/10.3389/fnins.2017.00316
Walls, N., & Meyers, A. (1984). Outcome in group treatments for bereavement: Experimental results and recommendations for clinical practice. International Journal of Mental Health, 13(3/4), 126–147.
Webb, C. A., Olson, E. A., Killgore, W. D. S., Pizzagalli, D. A., Rauch, S. L., & Rosso, I. M. (2017). Rostral anterior cingulate cortex morphology predicts treatment response to internet-based CBT for depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. https://doi.org/10.1016/j.bpsc.2017.08.005
Yudkin, J. S., Kumari, M., Humphries, S. E., & Mohamed-Ali, V. (2000). Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis, 148(2), 209–214.
Zisook, S., & Shear, K. (2009). Grief and bereavement: what psychiatrists need to know. World Psychiatry: Official Journal of the World Psychiatric Association (WPA), 8(2), 67–74.
Zisook, S., Shuchter, S. R., Pedrelli, P., Sable, J., & Deaciuc, S. C. (2001). Bupropion sustained release for bereavement: results of an open trial. The Journal of Clinical Psychiatry, 62(4), 227–230.
Zisook, S., Shuchter, S. R., Sledge, P. A., Paulus, M., & Judd, L. L. (1994). The spectrum of depressive phenomena after spousal bereavement. The Journal of Clinical Psychiatry, 55 Suppl, 29–36.
Zorrilla, E. P., Luborsky, L., McKay, J. R., Rosenthal, R., Houldin, A., Tax, A., … Schmidt, K. (2001). The relationship of depression and stressors to immunological assays: a meta-analytic review. Brain, Behavior, and Immunity, 15(3), 199–226. https://doi.org/10.1006/brbi.2000.0597